191. The Gut-Immune Axis | Intestinal Secretory IgA, Lactoferrin, and Lactoferrin Levels
Description
In this encore episode, we detail the gut-immune axis, focusing on the protective mucus layer and the roles of secretory immunoglobulin A and lactoferrin in intestinal health. We discuss endogenous secretions as well as highlight lactoferrin testing and levels.
Topics:
1. The Intestinal Barrier & Mucus Layer
- The intestinal lumen, microbiome, mucus layer, epithelial cells, and lamina propria.
- The mucus layer: antimicrobial peptides (AMPs) and secretory IgA (sIgA).
- Intestinal epithelial cells including goblet cells and enterocytes.
2. Immune Cells in the Gut
- The lamina propria.
- Macrophages, dendritic cells, neutrophils, B cells, T cells, mast cells, and more.
3. Antimicrobial Peptides & Secretory IgA
- AMPs and sIgA in the mucus layer aid in regulating microbial balance and pathogen adhesion.
4. Lactoferrin: Functions & Sources
- Iron-binding glycoprotein, antimicrobial and immunomodulatory properties.
- Found in mucosal secretions, colostrum, and more.
- Intestinal epithelial cells (IECs) and neutrophils.
5. Lactoferrin’s Role in Intestinal Health
- Regulates iron absorption via lactoferrin receptors (LFR)on enterocytes.
- Sequesters free iron, limiting bacterial growth, bacteriostatic.
- Destabilizes bacterial membranes, cell lysis, bactericidal.
6. Lactoferrin Levels
- Neutrophils release lactoferrin during infection,increasing its presence in the large intestine.
- Fecal lactoferrin levels.
- Fecal calprotectin levels.
7. Candida Overgrowth
8. Lactoferrin Supplementation to Support the Gut
9. Conclusion
- The intestinal mucus layer.
- Lactoferrin.
Thank you to our episode sponsor:
1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX
2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract.
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